Video: Vim li cas pentose phosphate txoj kev hu ua HMP shunt?
2024 Tus sau: Stanley Ellington | [email protected]. Kawg hloov kho: 2023-12-16 00:17
Yog ib pentose phosphate txoj kev hu ua ib shunt ? Nws yog hu ua tus pentose phosphate kaw vim txoj kev tso cai rau carbon atoms los ntawm qabzib 6- phosphate mus taug kev luv luv (a shunt ) ua ntej lawv mus rau hauv Embden-Meyerhof (glycolytic) txoj kev.
Cov lus nug tseem yog, lub hom phiaj ntawm HMP shunt yog dab tsi?
Cov hexose monophosphate shunt , tseem hu ua pentose phosphate txoj kev, yog ib txoj hauv kev tshwj xeeb siv los tsim cov khoom tseem ceeb hauv lub cev rau ntau yam. Cov HMP swb yog lwm txoj hauv kev rau glycolysis thiab siv los tsim ribose-5-phosphate thiab nicotinamide adenine dinucleotide phosphate (NADPH).
Ib tug kuj yuav nug, qhov twg HMP shunt tshwm sim? Qhov chaw ntawm txoj kev • Cov enzymes nyob hauv cytosol. Cov ntaub so ntswg xws li daim siab, cov ntaub so ntswg adipose, qog adrenal, erythrocytes, testes & lactating mammary gland, yog cov nquag nquag hauv HMP swb.
Ib yam li ntawd, lub ntsiab lus ntawm txoj kev pentose phosphate yog dab tsi?
Cov pentose phosphate txoj kev feem ntau yog catabolic thiab ua haujlwm ua lwm yam qabzib oxidizing txoj kev rau tiam ntawm NADPH uas yuav tsum tau rau txo cov biosynthetic tshuaj xws li cov cholesterol biosynthesis, bile acid synthesis, steroid hormone biosynthesis, thiab fatty acid synthesis.
Muaj pes tsawg ATP raug tsim nyob rau hauv HMP shunt?
Hauv HMP shunt, 12 khub ntawm hydrogen atoms thaum kawg hloov mus rau oxygen yielding 12 3 = 36 ATP. Ntawm no, 1 ATP yog siv los hloov ib qho molecule ntawm dawb qabzib-6 phosphate. Li no, cov txiaj ntsig tau yog 35 ATP uas piv tau zoo nrog 38 ATP tau los ntawm glycolysis thiab TCA lub voj voog.
Pom zoo:
Lub luag haujlwm ntawm pentose phosphate txoj kev yog dab tsi?
Txoj kev pentose phosphate feem ntau yog catabolic thiab ua haujlwm raws li lwm txoj hauv kev ua kom qabzib oxidizing txoj hauv kev rau tiam ntawm NADPH uas yuav tsum muaj rau kev txo qis biosynthetic xws li cov roj cholesterol biosynthesis, bile acid synthesis, steroid hormone biosynthesis, thiab fatty acid synthesis
Puas yog txoj kev pentose phosphate xav tau oxygen?
PPP tsis haus lossis tsim ATP thiab tsis xav tau cov pa oxygen molecular. Nyob rau thaum ntxov 'oxidative theem' ntawm PPP, thaum lub sij hawm uas thawj cov pa roj carbon monoxide lub cev pob txha ploj li carbon dioxide, nicotinamide adenine dinucleotide phosphate (NADP +) hloov mus rau NADPH
Muaj pes tsawg ATP raug tsim nyob rau hauv txoj kev pentose phosphate?
Lub ntsiab enzyme ntawm txoj kev yog 6-phosphogluconate dehydrogenase. Tom qab cleavage ntawm pentose phosphate feem ntau tsim glyceraldehyde 3-phosphate thiab acetate los yog acetyl phosphate (nyob ntawm seb lub enzyme system). Qhov txiaj ntsig ntawm ATP rau txoj hauv kev no feem ntau tsuas yog 1 ATP rau cov piam thaj molecule
Lub hom phiaj ntawm cov theem nonoxidative ntawm pentose phosphate shunt yog dab tsi?
Cov teeb meem ntawm pentose metabolism Txoj hauv kev pentose phosphate yog lwm txoj hauv kev rau glycolysis thiab tsim NADPH ( theem oxidative) thiab pentoses (5-carbon suab thaj, theem nonoxidative). Nws kuj tseem metabolizes noj pentoses thiab muab glycolytic / gluconeogenic intermediates
Lub hom phiaj ntawm non oxidative theem ntawm pentose phosphate txoj kev yog dab tsi?
Cov theem tsis-oxidative tsim 5-carbon suab thaj, uas tuaj yeem siv rau hauv kev sib txuas ntawm nucleotides, nucleic acids, thiab amino acids. Txoj kev pentose phosphate yog lwm txoj hauv kev rau glycolysis