Lub hom phiaj ntawm cov theem nonoxidative ntawm pentose phosphate shunt yog dab tsi?
Lub hom phiaj ntawm cov theem nonoxidative ntawm pentose phosphate shunt yog dab tsi?

Video: Lub hom phiaj ntawm cov theem nonoxidative ntawm pentose phosphate shunt yog dab tsi?

Video: Lub hom phiaj ntawm cov theem nonoxidative ntawm pentose phosphate shunt yog dab tsi?
Video: HMP Shunt (Pentose phosphate pathway) شرح بالعربي 2024, Kaum ib hlis
Anonim

Kev puas tsuaj ntawm pentose metabolism

Cov pentose phosphate txoj kev yog lwm txoj hauv kev rau glycolysis thiab tsim NADPH ( oxidative theem ) thiab pentoses (5-carbon qab zib, nonoxidative theem ). Nws kuj metabolizes kev noj haus pentoses thiab muab glycolytic/gluconeogenic intermediates.

Ntawm no, lub hom phiaj ntawm txoj kev pentose phosphate yog dab tsi?

Cov pentose phosphate txoj kev feem ntau yog catabolic thiab ua lwm yam qabzib oxidizing txoj kev rau tiam ntawm NADPH uas yuav tsum tau rau txo cov biosynthetic tshuaj xws li cov cholesterol biosynthesis, bile acid synthesis, steroid hormone biosynthesis, thiab fatty acid synthesis.

Tsis tas li ntawd, dab tsi yog pentose shunt? Cov pentose phosphate pathway (PPP; kuj hu ua phosphogluconate txoj kev thiab hexose monophosphate shunt ) yog cov txheej txheem uas zom cov piam thaj-6-phosphate rau hauv NADPH thiab pentoses (5-carbon qab zib) siv rau hauv cov txheej txheem hauv qab dej.

Hauv qhov no, lub hom phiaj ntawm kev tsis yog oxidative ntawm pentose phosphate txoj kev yog dab tsi?

Cov tsis yog - oxidative theem : Qhov no tso cai rau sib txawv molecules nkag rau hauv pentose phosphate txoj kev nyob rau hauv ntau qhov chaw ntawm lub tsis yog - oxidative theem thiab yuav hloov mus txog rau thaum thawj molecule ntawm lub tsis yog - oxidative theem (Ribulose-5- phosphate ).

Dab tsi yog qhov tseem ceeb ntawm hexose monophosphate shunt?

G6PD yog ib qho enzyme nyob rau hauv hexose monophosphate txoj kev, biochemical txoj kev rau metabolizing. qabzib uas hla txoj kev glycolytic. Lub hexose monophosphate shunt yog tsim nyog rau tiam ntawm NADPH, uas nyob rau hauv lem yuav tsum tau regenerate txo glutathione los ntawm nws daim ntawv oxidized.

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