Lub luag haujlwm ntawm pentose phosphate txoj kev yog dab tsi?
Lub luag haujlwm ntawm pentose phosphate txoj kev yog dab tsi?

Video: Lub luag haujlwm ntawm pentose phosphate txoj kev yog dab tsi?

Video: Lub luag haujlwm ntawm pentose phosphate txoj kev yog dab tsi?
Video: Pentose Phosphate Pathway - Regulation, Purpose and Importance in Human Health 2024, Kaum ib hlis
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Cov pentose phosphate txoj kev feem ntau yog catabolic thiab ua lwm yam qabzib oxidizing txoj kev rau tiam ntawm NADPH uas yuav tsum tau rau txo cov biosynthetic tshuaj xws li cov cholesterol biosynthesis, bile acid synthesis, steroid hormone biosynthesis, thiab fatty acid synthesis.

Tom qab ntawd, dab tsi yog cov khoom tseem ceeb ntawm pentose phosphate txoj kev?

Txoj kev pentose phosphate siv qhov chaw hauv cytosol ntawm lub cell, tib qhov chaw raws li glycolysis. Ob yam khoom tseem ceeb tshaj plaws los ntawm cov txheej txheem no yog ribose-5-phosphate qab zib siv los ua DNA thiab RNA, thiab cov NADPH molecules uas pab tsim lwm yam molecules.

Ib sab saum toj no, leej twg nrhiav tau pentose phosphate? Cov nrhiav pom Xyoo 1931-1935 los ntawm German biochemist, Otto Warburg, ntawm oxidative division ntawm lub txoj kev thiab ntawm chemistry thiab lub luag hauj lwm ntawm ib tug tshiab pyridine nucleotide co-enzyme nyob rau hauv nws cov tshuaj tiv thaiv yog deliniated.

Ib yam li ntawd, tib neeg nug, puas yog txoj kev pentose phosphate xav tau oxygen?

Lub PPP ua tsis haus lossis tsim ATP thiab ua tsis yog xav tau molecular cov pa . Nyob rau thaum ntxov ' oxidative theem' ntawm PPP, thaum lub sij hawm uas thawj cov pa roj carbon monoxide lub cev pob txha ploj li carbon dioxide, nicotinamide adenine dinucleotide. phosphate (NADP+) hloov dua siab tshiab rau NADPH.

Dab tsi yog tsim nyob rau hauv pentose phosphate txoj kev?

Cov pentose phosphate txoj kev (tseem hu ua phosphogluconate txoj kev thiab hexose monophosphate shunt) yog ib qho metabolic txoj kev parallel rau glycolysis. Nws tsim NADPH thiab pentoses (5-carbon qab zib) thiab riwb 5 - phosphate , ib tug precursor rau synthesis ntawm nucleotides.

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