Lub ubiquitin system ua haujlwm li cas hauv cov hlwb?
Lub ubiquitin system ua haujlwm li cas hauv cov hlwb?

Video: Lub ubiquitin system ua haujlwm li cas hauv cov hlwb?

Video: Lub ubiquitin system ua haujlwm li cas hauv cov hlwb?
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Cov ubiquitin - proteasome qhov system Nws yog lub luag haujlwm rau kev degradation ntawm feem ntau cov proteins hauv lub cev thiab yog li ua lub luag haujlwm tseem ceeb hauv kev tswj hwm qhov tseem ceeb. cellular cov txheej txheem suav nrog cell Kev loj hlob ntawm lub voj voog, kev loj hlob, kev sib txawv, angiogenesis thiab apoptosis.

Hauv qhov no, ubiquitin system ua haujlwm li cas?

Cov ubiquitin system encompasses cov enzymes xav tau rau catalysing txuas ntawm ubiquitin rau substrates nrog rau cov proteins uas khi rau ubiquitinated cov proteins coj lawv mus rau lawv txoj hmoo kawg. Qhov tseem ceeb, ntau yam ntawm biotic thiab abiotic kev ntxhov siab yuav xav tau, lossis yog modulated los ntawm, kev ubiquitination.

Lub luag haujlwm ntawm ubiquitin yog dab tsi? Ubiquitination cuam tshuam cov txheej txheem cellular los ntawm kev tswj cov degradation ntawm cov proteins (ntawm cov proteasome thiab lysosome), kev sib koom tes ntawm cellular localization ntawm cov proteins, activating thiab inactivating proteins, thiab modulating protein-protein kev sib tshuam.

Hauv qhov no, ubiquitin proteasome system yog dab tsi?

Cov Ubiquitin / Proteasome System (UPS) yog ib qho kev tswj hwm zoo heev ntawm cov protein degradation thiab kev hloov pauv hauv lub cev. Los ntawm kev sib koom ua ke ntawm ntau cov enzymes, cov proteins raug cim rau proteasomal degradation los ntawm kev txuas mus rau polypeptide co-factor, ubiquitin.

Qhov twg ubiquitination tshwm sim nyob rau hauv lub cell?

Cov ubiquitin -proteasome system muaj nyob rau hauv ob qho tib si cytoplasm thiab lub nucleus thiab yog lub luag haujlwm rau kev degradation ntawm ntau lub cellular proteins luv luv. Ubiquitination ntawm lub hom phiaj protein tuaj yeem tshwm sim ntawm ib pawg ε-amino ntawm ib qho lysine sab hauv lossis ntawm N terminus ntawm cov protein tagged rau kev puas tsuaj.

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