Lub ubiquitin system ua haujlwm li cas?

2024 Tus sau: Stanley Ellington | [email protected]. Kawg hloov kho: 2023-12-16 00:17

Cov ubiquitin system encompasses cov enzymes xav tau rau catalysing txuas ntawm ubiquitin rau substrates nrog rau cov proteins uas khi rau ubiquitinated cov proteins coj lawv mus rau lawv txoj hmoo kawg. Qhov tseem ceeb, ntau yam ntawm biotic thiab abiotic kev ntxhov siab yuav xav tau, lossis yog modulated los ntawm, kev ubiquitination.

Tsis tas li ntawd, ubiquitin system ua haujlwm li cas hauv cov hlwb?

Cov ubiquitin -proteasome lawv Nws yog lub luag haujlwm rau kev degradation ntawm feem ntau cov proteins hauv lub cev thiab yog li ua lub luag haujlwm tseem ceeb hauv kev tswj hwm qhov tseem ceeb. cellular cov txheej txheem suav nrog ntawm tes Kev loj hlob ntawm lub voj voog, kev loj hlob, kev sib txawv, angiogenesis thiab apoptosis.

Tsis tas li ntawd, ubiquitin ua haujlwm li cas? Mechanism ntawm Ubiquitination 76 amino acid protein ubiquitin yog thawj qhib los ntawm a ubiquitin activating enzyme (E1) nyob rau hauv cov txheej txheem ntawm ATP. Ib E2 ubiquitin conjugating enzyme ces hloov activated ubiquitin ntawm thioester daim ntawv cog lus rau cysteine residue hauv nws qhov chaw nquag.

Ib yam li ntawd, koj tuaj yeem nug, ubiquitin yog dab tsi thiab nws txoj haujlwm yog dab tsi?

Ubiquitination cuam tshuam cov txheej txheem cellular los ntawm kev tswj cov degradation ntawm cov proteins (ntawm cov proteasome thiab lysosome), kev sib koom tes ntawm cellular localization ntawm cov proteins, activating thiab inactivating proteins, thiab modulating protein-protein kev sib tshuam.

Dab tsi yog qhov ubiquitin proteasome system?

Cov Ubiquitin / Proteasome System (UPS) yog ib qho kev tswj hwm zoo heev ntawm cov protein degradation thiab kev hloov pauv hauv cov cell. Los ntawm kev sib koom ua ke ntawm ntau cov enzymes, cov proteins raug cim rau proteasomal degradation los ntawm kev txuas mus rau polypeptide co-factor, ubiquitin.