Lub luag haujlwm ntawm ubiquitin hauv cov protein yog dab tsi?

2024 Tus sau: Stanley Ellington | [email protected]. Kawg hloov kho: 2023-12-16 00:17

Ubiquitination cuam tshuam cov txheej txheem cellular los ntawm kev tswj cov degradation ntawm cov proteins (ntawm cov proteasome thiab lysosome), kev sib koom tes ntawm cellular localization ntawm cov proteins , activating thiab inactivating cov proteins , thiab modulating protein ntau - protein ntau kev sib tshuam.

Yog li ntawd, lub luag haujlwm ntawm ubiquitin yog dab tsi?

Ubiquitin yog ib qho protein me me uas muaj nyob hauv yuav luag tag nrho cov cellular cov ntaub so ntswg hauv tib neeg thiab lwm yam kab mob eukaryotic, uas pab tswj cov txheej txheem ntawm lwm cov proteins hauv lub cev.

ubiquitin proteasome yog dab tsi? Cov Ubiquitin Proteasome Pathway (UPP) yog lub luag haujlwm tseem ceeb rau cov protein catabolism hauv cov tsiaj txhu cytosol thiab nucleus. Cov kev tswj hwm zoo UPP cuam tshuam rau ntau yam ntawm cov txheej txheem ntawm tes thiab cov txheej txheem substrates thiab qhov tsis xws luag hauv cov kab ke tuaj yeem ua rau muaj kev cuam tshuam ntawm ntau yam kab mob tseem ceeb ntawm tib neeg.

Tom qab ntawd, lo lus nug yog, ubiquitin tswj cov protein li cas?

Kev tshem tawm lossis hloov kho cov saw hlau polyubiquitin cuam tshuam rau txoj hmoo ntawm lub hom phiaj protein ntau . DUB tuaj yeem tswj tau protein ntau stability los ntawm kev tso tawm ntawm ubiquitin molecules los ntawm kev hloov pauv substrates ua ntej kev lees paub los ntawm 26S proteasome, txwv tsis pub protein ntau degradation.

Qhov twg ubiquitination tshwm sim?

Cov ubiquitin -proteasome system muaj nyob rau hauv ob qho tib si cytoplasm thiab lub nucleus thiab yog lub luag haujlwm rau kev degradation ntawm ntau lub cellular proteins luv luv. Ubiquitination ntawm lub hom phiaj protein tuaj yeem tshwm sim ntawm ib pawg ε-amino ntawm ib qho lysine sab hauv lossis ntawm N terminus ntawm cov protein tagged rau kev puas tsuaj.