Video: Dab tsi yog biotransformation hauv pharmacology?
2024 Tus sau: Stanley Ellington | [email protected]. Kawg hloov kho: 2023-12-16 00:17
Biotransformation yog kev hloov kho tshuaj (los yog kev hloov kho) ua los ntawm cov kab mob ntawm cov tshuaj lom neeg. Biotransformation txhais tau hais tias kev hloov pauv tshuaj ntawm cov tshuaj xws li cov as-ham, amino acids, co toxins, thiab tshuaj hauv lub cev.
Tom qab ntawd, txheej txheem biotransformation yog dab tsi?
Biotransformation yog cov txheej txheem los ntawm qhov uas ib yam khoom hloov ntawm ib qho tshuaj mus rau lwm qhov (hloov) los ntawm cov tshuaj tiv thaiv hauv lub cev. Metabolism lossis metabolic transformations yog cov ntsiab lus nquag siv rau cov txheej txheem biotransformation.
Tsis tas li ntawd, dab tsi yog conjugation ntawm cov tshuaj? Conjugation . Glucuronidation, feem ntau theem II cov tshuaj tiv thaiv, yog tib qho uas tshwm sim hauv daim siab microsomal enzyme system. Glucuronides tau tso tawm hauv cov kua tsib thiab tshem tawm hauv cov zis. Yog li, kev sib txuas ua rau feem ntau tshuaj ntau soluble thiab yooj yim excreted los ntawm lub raum.
Tom qab ntawd, lo lus nug yog, qhov chaw sib txawv ntawm cov tshuaj biotransformation yog dab tsi?
Tshuaj biotransformation los yog metabolism feem ntau tshwm sim nyob rau hauv daim siab, raum, daim tawv nqaij, thiab GI ib ntsuj av. Hauv lub siab, biotransformation Nws cuam tshuam nrog hydrolysis, oxidation, txo, lossis demethylation thiab kev sib txuas ntawm cov metabolite nrog glycine, glucuronide, sulfate, lossis hippurate nrog cov kua tsib tom qab tso rau hauv cov kua tsib.
Dab tsi yog qhov txawv ntawm biotransformation thiab metabolism?
Hauv luv luv, " metabolism ntawm tshuaj" yog ib daim ntawv ntawm biotransformation uas tshwm sim rau tshuaj hauv a lub cev, whereas " biotransformation " yog ib lo lus dav dav uas siv sib npaug zoo rau kev ua ntawm cov enzyme disembodied zom cov roj slick.
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