Ubiquitination txhais li cas?
Ubiquitination txhais li cas?

Video: Ubiquitination txhais li cas?

Video: Ubiquitination txhais li cas?
Video: Ubiquitin 2024, Kaum ib hlis
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Ubiquitination : Cov txheej txheem "hnia ntawm kev tuag" rau cov protein. Hauv kev ubiquitination , ib qho protein yog inactivated los ntawm kev txuas ubiquitin rau nws. Ubiquitin yog ib tug me me molecule. Nws ua raws li ib daim ntawv teev cov khoom siv thauj khoom thauj mus rau cov protein mus rau cov proteasome rau kev degradation.

Tom qab ntawd, ib tug kuj yuav nug, qhov twg ubiquitination tshwm sim?

Cov ubiquitin -proteasome system muaj nyob rau hauv ob qho tib si cytoplasm thiab lub nucleus thiab yog lub luag haujlwm rau kev degradation ntawm ntau lub cellular proteins luv luv. Ubiquitination ntawm lub hom phiaj protein tuaj yeem tshwm sim ntawm ib pawg ε-amino ntawm ib qho lysine sab hauv lossis ntawm N terminus ntawm cov protein tagged rau kev puas tsuaj.

Ib tug kuj yuav nug, dab tsi amino acid puas ubiquitination tshwm sim? Ubiquitination yog ib qho me me (76-amino acid) protein uas tau txais kev txuag thiab nthuav dav hauv txhua lub hlwb eukaryotic. Ubiquitination muaj ib los yog ntau dua covalent ntxiv rau cov lysine residues ntawm lub hom phiaj proteins.

Xav txog qhov no, ubiquitin yog dab tsi thiab nws txoj haujlwm yog dab tsi?

Ubiquitination cuam tshuam cov txheej txheem cellular los ntawm kev tswj cov degradation ntawm cov proteins (ntawm cov proteasome thiab lysosome), kev sib koom tes ntawm cellular localization ntawm cov proteins, activating thiab inactivating proteins, thiab modulating protein-protein kev sib tshuam.

Puas yog ubiquitination thim rov qab?

Ubiquitination yog thim rov qab . Cov protein hloov pauv tuaj yeem deubiquitinated, tshem tawm ubiquitin molecules los ntawm substrate. Deubiquitinating enzymes (DUBs) yog proteases uas hydrolyze cov isopeptide bond ntawm cov ubiquitin C-terminus thiab cov amino pawg ntawm cov lysine residues (Komander, 2010).

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