Video: Ubiquitination txhais li cas?
2024 Tus sau: Stanley Ellington | [email protected]. Kawg hloov kho: 2023-12-16 00:17
Ubiquitination : Cov txheej txheem "hnia ntawm kev tuag" rau cov protein. Hauv kev ubiquitination , ib qho protein yog inactivated los ntawm kev txuas ubiquitin rau nws. Ubiquitin yog ib tug me me molecule. Nws ua raws li ib daim ntawv teev cov khoom siv thauj khoom thauj mus rau cov protein mus rau cov proteasome rau kev degradation.
Tom qab ntawd, ib tug kuj yuav nug, qhov twg ubiquitination tshwm sim?
Cov ubiquitin -proteasome system muaj nyob rau hauv ob qho tib si cytoplasm thiab lub nucleus thiab yog lub luag haujlwm rau kev degradation ntawm ntau lub cellular proteins luv luv. Ubiquitination ntawm lub hom phiaj protein tuaj yeem tshwm sim ntawm ib pawg ε-amino ntawm ib qho lysine sab hauv lossis ntawm N terminus ntawm cov protein tagged rau kev puas tsuaj.
Ib tug kuj yuav nug, dab tsi amino acid puas ubiquitination tshwm sim? Ubiquitination yog ib qho me me (76-amino acid) protein uas tau txais kev txuag thiab nthuav dav hauv txhua lub hlwb eukaryotic. Ubiquitination muaj ib los yog ntau dua covalent ntxiv rau cov lysine residues ntawm lub hom phiaj proteins.
Xav txog qhov no, ubiquitin yog dab tsi thiab nws txoj haujlwm yog dab tsi?
Ubiquitination cuam tshuam cov txheej txheem cellular los ntawm kev tswj cov degradation ntawm cov proteins (ntawm cov proteasome thiab lysosome), kev sib koom tes ntawm cellular localization ntawm cov proteins, activating thiab inactivating proteins, thiab modulating protein-protein kev sib tshuam.
Puas yog ubiquitination thim rov qab?
Ubiquitination yog thim rov qab . Cov protein hloov pauv tuaj yeem deubiquitinated, tshem tawm ubiquitin molecules los ntawm substrate. Deubiquitinating enzymes (DUBs) yog proteases uas hydrolyze cov isopeptide bond ntawm cov ubiquitin C-terminus thiab cov amino pawg ntawm cov lysine residues (Komander, 2010).
Pom zoo:
Kev txhais lus txhais li cas hauv kev tsim kho?
Cov ko taw yog ib feem tseem ceeb ntawm kev tsim kho hauv paus. Lawv feem ntau yog ua los ntawm pob zeb nrog rebar reinforcement uas tau muab nchuav rau hauv ib qho kev khawb av. Lub hom phiaj ntawm footings yog los txhawb lub hauv paus thiab tiv thaiv kev sib haum xeeb. Ib tug footing yog muab tso rau hauv qab ntawm Frost kab thiab ces cov phab ntsa ntxiv rau saum
Cov txhais lus yooj yim txhais li cas?
Parliament. Lub ntsiab lus feem ntau ntawm parliament yog hais txog lub teb chaws txoj cai lij choj (kev cai lij choj) lub cev. England lub rooj sib tham muaj npe nrov heev. Lo lus los ib feem los ntawm lus Fab Kis parler, uas txhais tau hais lus, uas ua rau muaj kev nkag siab txij li pab pawg neeg no sib sau los tham txog kev cai lij choj thiab teeb meem
Yuav ua li cas yog ib tug high accounts payable turnover txhais li cas?
Accounts Payable Turnover Txhais. Tus as-qhauj them tus nqi hloov pauv qhia tau hais tias pes tsawg lub sijhawm uas lub tuam txhab them tawm nws cov neeg xa khoom thaum lub sijhawm sau nyiaj. Nws kuj ntsuas seb lub tuam txhab tswj hwm kev them nws tus kheej li cas. Ib qho piv txwv siab dua feem ntau yog qhov zoo dua vim tias cov nyiaj them tau raug them sai dua
Kev huv txhais tes txhais li cas hauv txoj cai?
Cov tes huv si, qee zaum hu ua cov lus qhuab qhia huv tes los yog cov lus qhuab qhia ntawm tes qias neeg, yog kev tiv thaiv kev ncaj ncees uas tus neeg foob hais tias tus foob tsis muaj cai tau txais kev ncaj ncees vim tus foob ua txhaum cai lossis tau ua phem rau kev ntseeg. qhov kev tsis txaus siab-
Cov nyiaj txhais tes txhais li cas hauv kev muag tub ceev xwm?
Cov nyiaj tau los ntawm kev muag khoom yog siv los them cov qiv nyiaj qiv, tsev txhab nyiaj, cov neeg sau se, thiab lwm tus neeg foob uas tau poob nyiaj ntawm lub tsev. Kev muag tub ceev xwm tshwm sim thaum kawg ntawm cov txheej txheem foreclosure thaum tus tswv tsev thawj zaug tsis tuaj yeem ua qhov zoo ntawm nws cov nqi tsev