Video: Trinucleotide rov nthuav dav tshwm sim li cas?
2024 Tus sau: Stanley Ellington | [email protected]. Kawg hloov kho: 2023-12-16 00:17
Trinucleotide rov ua dua Cov kab mob yog cov kab mob ntawm caj ces tshwm sim los ntawm trinucleotide rov nthuav dav , ib hom kev hloov nyob rau hauv uas rov ua dua ntawm peb nucleotides ( trinucleotide rov ua dua ) nce hauv cov lej luam kom txog thaum lawv hla qhov chaw pib saum toj no uas lawv tsis ruaj khov.
Ib yam li ntawd, nws tau nug, dab tsi ua rau trinucleotide rov nthuav dav?
Kev hloov pauv, hu ua " trinucleotide rov ua dua (TNR) nthuav dav ,” tshwm sim thaum tus naj npawb ntawm triplets tam sim no nyob rau hauv ib tug mutated gene yog ntau dua li cov muaj nyob rau hauv ib txwm gene [1–3]. Tsis tas li ntawd, tus naj npawb ntawm triplets nyob rau hauv tus kab mob gene txuas ntxiv mus ntxiv raws li tus kab mob gene yog xeeb los (Fig.
Kuj Paub, kab mob dab tsi tshwm sim los ntawm trinucleotide repeats? Yam tsawg kawg yog xya qhov teeb meem tshwm sim los ntawm trinucleotide rov nthuav dav: X-txuas qaum qaum thiab pob txha pob txha atrophy (SBMA), ob lub X mob tsis yooj yim ntawm kev puas hlwb (FRAXA thiab FRAXE), myotonic dystrophy , Huntington's disease, spinocerebellar ataxia type 1 (SCA1), thiab dentatorubral-pallidoluysian atrophy (DRPLA).
Hais txog qhov no, dab tsi yog trinucleotide rov nthuav dav?
A trinucleotide rov nthuav dav , kuj hu ua a triplet rov nthuav dav , yog DNA kev hloov pauv lub luag haujlwm ua rau txhua yam kev tsis sib haum xeeb categorized li a trinucleotide rov ua dua tsis meej pem. Triplet expansion yog tshwm sim los ntawm slippage thaum lub sij hawm DNA replication, tseem hu ua "kev xaiv" DNA replication.
Dab tsi yog trinucleotide rov ua ntu zus hauv Huntington?
HTT kev hloov pauv uas ua rau muaj tus kab mob Huntington suav nrog a DNA ntu hu ua CAG trinucleotide rov ua dua. Ntu no yog ua los ntawm ib tug series ntawm peb DNA lub tsev thaiv (cytosine, adenine, thiab guanine) uas tshwm sim ntau zaus hauv kab. Feem ntau, CAG ntu tau rov ua dua 10 mus rau 35 zaug hauv cov noob.
Pom zoo:
Vim li cas trinucleotide rov ua rau muaj kab mob?
Triplet Expansion Disorders Cov trinucleotide rov tsis zoo (tseem hu ua trinucleotide repeat expansion disorders lossis triplet repeat expansion disorders) yog ib txheej ntawm cov kab mob caj ces tshwm sim los ntawm kev nce ntawm cov trinucleotide rov ua dua hauv qee cov genes tshaj qhov qub, ruaj khov, pib
Dab tsi tshwm sim Milgram qhov kev sim?
Nws tau ua ib qho kev sim tsom mus rau qhov tsis sib haum xeeb ntawm kev mloog lus rau txoj cai thiab lub siab ntawm tus kheej. Milgram (1963) tau tshuaj xyuas kev ncaj ncees rau kev ua phem ntawm kev tua neeg uas muaj los ntawm cov neeg raug liam thaum Tsov Rog Ntiaj Teb Zaum II, Nuremberg Kev Ua Phem Txhaum Cai
Vim li cas txoj cai ntawm kev txo qis marginal rov tshwm sim?
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Yuav ua li cas yog vim li cas ambiguity tshwm sim?
Causal Ambiguity thiab Competitive Advantage Vulnerability Raws li tau hais nyob rau hauv qhov kev taw qhia, causal ambiguity muaj feem xyuam rau qhov tsis meej ntawm cov peev txheej thiab kev ua tau zoo thiab nws muaj nyob qhov twg tus txiav txim siab muaj kev nkag siab tsis tiav ntawm qhov ua rau nws lub tuam txhab ua tiav
Yuav ua li cas tshwm sim rau tus nqi sib npaug thiab ntau npaum li cas thaum muaj kev nce ntxiv hauv kev thov thiab nce hauv cov khoom?
Qhov kev thov nce ntxiv, txhua yam tsis hloov pauv, yuav ua rau tus nqi sib npaug nce; cov khoom siv yuav nce ntxiv. Kev txo qis hauv kev thov yuav ua rau tus nqi sib npaug; kom muaj nuj nqis yuav txo. Kev txo qis hauv cov khoom yuav ua rau tus nqi sib npaug nce; kom muaj nuj nqis yuav txo