Reverse transcription PCR siv rau dab tsi?
Reverse transcription PCR siv rau dab tsi?

Video: Reverse transcription PCR siv rau dab tsi?

Video: Reverse transcription PCR siv rau dab tsi?
Video: RT-PCR made EASY - Reverese Transcriptase PCR for detection and test of Viral DNA 2024, Kaum ib hlis
Anonim

RT - PCR ( Rov qab Transscriptase PCR ) RT - PCR yog siv nyob rau hauv kev tshawb fawb lub chaw soj nstuam los kawm gene qhia, piv txwv li hauv kev sim kom paub qhov txawv ntawm exons los ntawm introns, thiab tuaj yeem ua tau. siv soj ntsuam kuaj kab mob genetic kab mob thiab saib xyuas kev kho tshuaj.

Xav txog qhov no, dab tsi xav tau rau kev hloov pauv rov qab?

pib rov qab transcription , thim rov qab transcriptases yuav tsum muaj luv luv DNA oligonucleotide hu ua primer los khi rau nws cov kev sib txuas ntxiv ntawm RNA template thiab ua qhov pib rau kev sib txuas ntawm cov hlua tshiab.

Tsis tas li ntawd, vim li cas nws thiaj tseem ceeb rau kev siv cDNA rau PCR? cDNA muaj nws tus kheej qhov tseem ceeb hauv Polymerase Chain Reaction ( PCR ) txheej txheem. cDNA Nws yog qhov tshwm sim ntawm kev thim rov qab los ntawm cov enzymes hu ua thim rov qab transcriptases. Tam sim no, ua ib daim qauv ntawm cov genomic DNA , qhov no cDNA tuaj yeem ua haujlwm rau lub hom phiaj ntawm tus qauv DNA rau hauv vitro amplification thiab kev soj ntsuam tom qab.

Ua li no, qhov txawv ntawm lub sijhawm PCR thiab rov qab transcriptase PCR yog dab tsi?

RT - PCR yog siv los ua kom nthuav dav qhov hloov pauv ntawm DNA code; QPCR ntsuas qhov amplification. 3. RT - PCR yog rau amplification, thaum qPCR yog rau kom muaj nuj nqis.

Puas yog cDNA muab ob npaug rau?

Tsis zoo li RNA, DNA molecules tuaj yeem yooj yim cloned (cov no hu ua ' cDNA clones ') los ntawm kev ua cDNA ob - tso tseg thiab ligated rau vector DNA. Kev soj ntsuam ib ntus ntawm DNA yog yooj yim dua li ntawm RNA, yog li, cDNA yog daim ntawv tseem ceeb hauv kev tshuaj xyuas RNA, tshwj xeeb ntawm eukaryotic mRNA.

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